Из сценария к фильму «Особо важное задание» #021

2,4-Dinitrophenol (2,4-DNP or simply DNP) is a natural substance with the formula HOC6H3(NO2)2. It is a yellow, crystalline strong that has a sweet, musty odor. It sublimes, is unpredictable with steam, and is soluble in many natural solvents in addition to liquid alkaline services. When in a dry type, it is a high explosive and has an immediate surge risk. It is a precursor to other chemicals and is biochemically active, preventing adenosine triphosphate (ATP) production in cells with mitochondria.

Commercially, DNP is used as an antibacterial and as a non-selective bioaccumulating pesticide.

DNP is particularly helpful as a herbicide together with other carefully related dinitrophenol herbicides like 2,4-dinitro-o-cresol (DNOC), dinoseb and dinoterb. Given that 1998 DNP was withdrawn from farming usage. Currently, there are no actively signed up pesticides consisting of DNP in United States or Europe.

It is a chemical intermediate in the production of sulfur dyes, wood preservatives and picric acid. DNP has similarly been used to make photographic developers and dynamites. DNP is classified as a dynamite in the UK and USA.

In living cells, DNP functions as a proton ionophore, a representative that can shuttle bus protons (hydrogen cations) throughout biological membranes. It dissipates the proton gradient across mitochondria and chloroplast membranes, collapsing the proton motive force that the cell uses to produce the majority of its ATP chemical energy. Instead of producing ATP, the energy of the proton gradient is lost as heat.

DNP functions as a protonophore, permitting protons to leakage across the inner mitochondrial membrane and therefore bypass ATP synthase. This makes ATP energy production less effective. In effect, part of the energy that is generally produced from cellular respiration is squandered as heat. The ineffectiveness is proportional to the dosage of DNP that is taken. As the dose boosts and energy production is made more inefficient, metabolic rate boosts (and more fat is burned) in order to make up for the insufficiency and to satisfy energy needs. DNP is most likely the very best comprehended representative for uncoupling oxidative phosphorylation. The "phosphorylation" of adenosine diphosphate (ADP) by ATP synthase gets detached or "uncoupled" from oxidation.

"Dinitrophenol uncouples oxidative phosphorylation, causes release of calcium from mitochondrial stores and prevents calcium re-uptake. This causes totally free intracellular calcium and sets off muscle contraction and hyperthermia. Dantrolene avoids calcium release from the sarcoplasmic reticulum which reduces intracellular calcium. The resulting muscle relaxation allows heat dissipation. There is little danger to dantrolene administration. Due to the fact that dantrolene might operate in lessening hyperthermia caused by agents that inhibit oxidative phosphorylation, early administration may improve outcome.

DNP was commonly utilized in explosive mixes around the world. Shellite in the UK, Tridite in the United States, Tridita in Spain, MDPC/DD in France, MABT/MBT in Italy, and DNP in the USSR.

Nowadays, DNP is offered generally online under a variety of various names such as 'DNP', 'Dinosan', 'Dnoc', 'Solfo Black', 'Nitrophen', 'Aldifen' and 'Chemox'. The chemical is a yellow crystalline powder that has a sweet, musty smell and is soluble in water. The dosage of DNP per tablet varies from site to site nevertheless it is most frequently provided as either 100- or 200-mg pills. Some web sites have DNP readily available wholesale quantities, allowing users to purchase kilograms of DNP powder or hundreds/thousands of DNP-containing tablets.

DNP has in fact been provided for over a century, at first in the manufacture of munitions, due to its explosive property or commercial residential or commercial properties. From the 1930s onwards, there has actually been interest in its houses to increase the underlying metabolic rate, leading to an associated weight-loss. It appears that there has really been increasing interest and schedule of DNP-containing products on the internet. https://www.buydnponline.cc

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